CORDIS Project
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This project aims to understand how the malaria-causing parasite Plasmodium falciparum uses antigenic variation to evade the immune system. By investigating the molecular mechanisms behind the expression of variant surface proteins, it seeks to identify potential targets for new therapeutic strategies against malaria.
An important number of human and animal pathogens use antigenic variation of surface proteins as a mechanism to avoid destruction by the host s immune system.
Most escape mechanisms rely on the successive expression of members of gene families in a mutually exclusive manner, a biological process which remains elusive at the molecular level.
The protozoan pathogen Plasmodium falciparum, which infects up to 300 million people causing more than two million lives each year, undergoes antigenic varia…
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