CORDIS Project
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This project investigates acute myeloid leukemia, focusing on the role of endothelial cells in the bone marrow microenvironment. It aims to understand how these cells contribute to the disease and explore new therapeutic strategies using advanced genetic techniques.
Acute myeloid leukemias (AML) are aggressive blood cancers with poor overall prognosis.
The main intervention line is high-dose chemotherapy, often associated with resistance, relapse and long-term side effects.
Although predominantly considered as genetic diseases of the hematopoietic system, AML also affect the bone marrow (BM) microenvironment, which contributes to disease pathogenesis.
Particularly, we have revealed a thorough remodeling of the vascular tree, with endothelial cells (ECs) dis…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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