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PlasticLiver investigates how liver cells change identity to regenerate bile ducts, focusing on differences between regions in a mouse model of Alagille syndrome. The project aims to uncover the mechanisms behind liver cell plasticity and improve the quality of regenerated bile ducts, which could lead to new therapeuti…
The liver can regenerate thanks to a unique cell plasticity in which “terminally differentiated cells” change identity.
Hepatocytes, the most abundant cell type sustaining liver metabolism, can transdifferentiate into a completely different cell type to repair the bile duct epithelium, which entails not only a fate switch but also a conversion of epithelial polarity.
Despite this regenerative capacity, bile duct diseases present a major clinical challenge, often requiring a liver transplant.
Act…
KAROLINSKA INSTITUTET
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