CORDIS Project
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This project investigates how neurotransmitter receptors, specifically Glycine and GABAA receptors, move and interact within synapses. By using advanced imaging techniques, it aims to uncover the relationship between receptor dynamics and synaptic strength, focusing on both neuronal and glial cell contributions.
Neurons maintain a precise organization of their membrane into sub-domains with specific molecular compositions, together with the capacity to change it in response to plasticity events.
However, as seen with the tracking of single molecules, receptors in the plasma membrane continuously exchange between synaptic and extrasynaptic locations.
Interactions between neurotransmitter receptors and postsynaptic scaffold proteins control the distribution of receptors at synaptic and extrasynaptic sites…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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