CORDIS Project
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The project aims to create new optical probes for imaging G-quadruplex DNA structures in live cells. By developing platinum complexes that enhance phosphorescence upon DNA interaction, it seeks to visualize these structures in real-time, addressing limitations of current imaging techniques.
There has been increasing experimental evidence suggesting that tetra-stranded DNA structures (G-quadruplexes) play important biological roles in telomere function and maintenance, replication and transcription.
The most direct evidence for their existence has come from immuno-staining in fixed cells as well as from recent deep sequencing studies.
However, to date, we are still lacking tools that allows us to visualizing G-quadruplexes directly in live cells.
While several small-molecule probes…
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