CORDIS Project
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This project investigates the role of the JAK/STAT signaling pathway in human pluripotent stem cells. It aims to understand how this pathway influences cell metabolism and differentiation, contributing to advancements in stem cell research.
The naïve inner cell mass of the human embryo is characterized by unlimited developmental plasticity as it gives rise to all somatic and extraembryonic lineages.
Following implantation, extraembryonic and auto inductive signals prime pluripotent cells for differentiation toward the three germ layers.
Concomitantly, metabolic gene expression transits from oxidative phosphorylation towards a glycolytic metabolism.
This developmental progression can be recapitulated in vitro using human pluripotent…
UNIVERSITA DEGLI STUDI DI PADOVA
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