CORDIS Project
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This project explores the role of PML protein in acute promyelocytic leukaemia, focusing on its interaction with P53 and its impact on redox homeostasis. The goal is to restore PML signaling in cancers where it is disrupted, potentially leading to new therapeutic strategies.
In acute promyelocytic leukaemia (APL), retinoic acid (RA) and Arsenic trioxide (As) bind PML/RARA and promote its degradation.
Exploring the mechanistic bases for APL response to the RA/As combination, we found that upon PML/RARA degradation the normal PML allele activates a PML/P53 checkpoint absolutely required for APL cure in mice or patients.
Physiologically, PML behaves as an oxidative stress sensor and contributes to redox homeostasis. PML organizes nuclear bodies (NBs), domains that recr…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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Lebanon, Beirut
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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