CORDIS Project
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This research aims to understand the formation of lung neuroendocrine tumors (LNETs) by studying pulmonary neuroendocrine cells (PNECs). Using an organoid-based approach, the project will investigate the pathways involved in the transformation of PNECs, focusing on small cell lung cancer and atypical carcinoids.
The ultimate goal of my research is to elucidate pathways involved in lung neuroendocrine tumor (LNET) formation. LNETs arise from a rare lung cell population, called pulmonary neuroendocrine cells (PNECs) and account for 20- to 25% of all lung cancers.
Despite their involvement in LNETs and a number of other respiratory diseases, relatively little is known about the normal function of PNECs or their contribution to cancer development and progression.
Utilizing a novel organoid based strategy fo…
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
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