CORDIS Project
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The project investigates the virulence mechanisms of Streptococcus pneumoniae, a significant pathogen in children and vulnerable adults. It employs single-cell techniques to study the regulation of pneumolysin, a key virulence factor, to better understand its role in disease.
Streptococcus pneumoniae is a major pathogen causing invasive (pneumonia, meningitis, bacteraemia) and non-invasive (acute otitis media, sinusitis) disease in young children and in elderly and/or immuno-compromised adults.
The molecular mechanisms underlying S. pneumoniae virulence are not fully understood.
Single-cell methodologies, including the sub-cellular localization of proteins by fluorescence microscopy, have been instrumental in studying fundamental processes in bacteria and these metho…
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