CORDIS Project
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This project investigates how the bacterium Streptococcus pneumoniae uses variability in gene expression to enhance its ability to infect hosts. By studying the molecular mechanisms behind this variability, the research aims to identify new targets for anti-pneumococcal therapies.
Not all cells in bacterial populations exhibit exactly the same phenotype, even though they grow in the same environment and are genetically identical.
One of the main driving forces of phenotypic variation is stochasticity, or noise, in gene expression.
Possible molecular origins contributing to noise in protein synthesis are stochastic fluctuations in the biochemical reactions of gene expression itself, namely transcription and translation.The driving hypothesis of this application is that the…
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