CORDIS Project
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This project investigates how chronic mild stress affects specific neurons in the brain related to Major Depressive Disorder, focusing on sex differences. It aims to understand the role of prepronociceptin neurons in arousal responses and their connection to depressive behaviors in male and female mice.
Major Depressive Disorder (MDD) is a highly prevalent and disabling condition experienced by ~6% of the population worldwide.
Interestingly, women are twice as likely as men to suffer from MDD, and the specific mechanisms contributing to such difference are only starting to be elucidated.
Chronic mild stress has been shown to reproduce in rodents some of the main traits of MDD, such as anhedonia or anxiety-like behaviour.
Chronic stress has been shown to interfere with prepronociceptin (Pnoc) ex…
UNIVERSITAT AUTONOMA DE BARCELONA
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United States, Chapel Hill
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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