CORDIS Project
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This project aims to create genetically engineered bacteria that produce cyclic peptides to combat protein misfolding diseases like Alzheimer's and amyotrophic lateral sclerosis. It will demonstrate the delivery and effectiveness of these peptides in mouse models of ALS.
Within the ERC Consolidator Grant ProMiDis, my team and I have developed genetically engineered bacteria that function as a stand-alone, living discovery platform for short, drug-like cyclic peptides rescuing the misfolding and aggregation of proteins associated with human diseases (protein misfolding diseases, PMDs).
By applying this technology, we have discovered hundreds of new molecules-putative drugs against notorious PMDs, such as Alzheimer’s disease and amyotrophic lateral sclerosis (ALS)…
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