CORDIS Project
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This project investigates the mechanisms behind the high replication rates of malaria parasites in mammalian liver cells. By studying the unique liver metabolism, it aims to uncover how the parasite exploits host resources to enhance its life cycle and identify potential therapeutic targets against malaria.
Malaria remains the most serious parasitic infectious disease, killing one child every two minutes.
Plasmodium infection starts when the female Anopheles mosquito injects sporozoites into the skin of the vertebrate host.
All Plasmodium species go through a phase of replication inside nucleated cells prior to infecting red blood cells and causing malaria, however, only mammalian-infectious parasites target the liver and replicate inside hepatocytes at an extraordinary rate to generate tens of tho…
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