CORDIS Project
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This project investigates integrin activation and its role in cell adhesion and signaling. By using advanced measurement techniques, it aims to uncover the physical principles behind integrin function and improve strategies for therapeutic interventions.
Integrin-mediated adhesion to the extracellular matrix is a prerequisite for the development and homeostasis of multicellular organisms. A hallmark of integrins is that ligand binding requires an “integrin activation” step affecting the shape of the entire molecule is induced by the integrin tail- and actomyosin-binding adaptor proteins talin and kindlin.
In a second step, integrins cluster and assemble a gigantic signaling hub, where they integrate biochemical and biophysical signals to achieve…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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Germany, Muenchen
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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