CORDIS Project
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This project investigates the role of the Ccr4-Not complex in regulating mRNA synthesis and degradation, which are crucial for gene expression. By employing advanced techniques, the research aims to uncover mechanisms that could lead to new insights in medical research and drug development.
Eukaryotic gene expression is tightly regulated at all stages of the mRNA life cycle, from mRNA synthesis in the nucleus to mRNA degradation in the cytoplasm.
Defects in gene regulation cause serious defects in cells, and severe pathologies in humans, such as cancer, diabetes, and cardiovascular disease.
The host lab recently made the seminal discovery that mRNA synthesis and degradation are coupled processes.
The nine-subunit Ccr4-Not complex emerged as a candidate for a so far elusive coupling…
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
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