CORDIS Project
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This project investigates the interactions between RNA Polymerase II and transcription factors to understand the mechanisms maintaining their spatial organization. It employs electromagnetic imaging and computer simulations to identify key amino acids and explore the effects of phosphorylation on these interactions, wi…
RNA Polymerase II (Pol II) plays a pivotal role in human cellular function, carrying out the complex transcription process. A unique domain sits at the end of Pol II, the C-Terminal Domain (CTD), the phosphorylation of which offers a mechanism of interaction for transcription factors (TFs) that regulate the transcription process.
The spatial organization of TFs around Pol II is moderated by the intrinsically disordered regions (IDRs) of the TFs and CTD, and high specificity is required to avoid…
Masarykova univerzita
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