CORDIS Project
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This project focuses on understanding how Plasmodium parasites develop within liver cells during malaria infection. It examines the role of hepatocyte polarization in creating a supportive environment for the parasite's growth and aims to identify key molecular interactions.
Plasmodium parasites are the causative agents of malaria, amongst the most prevalent and severe human infectious diseases.
Plasmodium sporozoites are injected into the mammalian host during the bite of an anopheline mosquito, and rapidly migrate to the liver where they invade hepatocytes.
Once inside a hepatocyte, a single sporozoite initiates a developmental program whereby it gives rise to thousands of merozoites, which are released into the blood stream a few days later, initiating the clin…
INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
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