CORDIS Project
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This project investigates how the PIDDosome complex regulates the number of centrosomes in cells, which is crucial for maintaining proper chromosome sets. It aims to explore its implications for cancer, inflammation, and regenerative medicine by targeting this complex for therapeutic development.
Tight control of the number of chromosome sets in a cell (ploidy) is fundamental for normal development and organismal health.
Most cells in our body are diploid, yet, some cells, including cardiomyocytes or hepatocytes require a balanced increase in ploidy for proper function.
Polyploidization is accompanied by an accumulation of centrosomes, structures needed for nucleating the mitotic spindle and ciliogenesis.
Extra centrosomes, however, promote aneuploidy in proliferating cells by causing er…
MEDIZINISCHE UNIVERSITAT INNSBRUCK
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