CORDIS Project
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This project aims to understand the mechanisms behind spinal and bulbar muscular atrophy (SBMA) by investigating the role of specific proteins and their interactions in neuronal vulnerability. It will explore how modifications in protein behavior affect disease progression.
Spinal and bulbar muscular atrophy (SBMA) is one of nine polyglutamine diseases and is caused by expansion of CAG in the androgen receptor (AR) gene.
Despite the widespread distribution of polyglutamine proteins in the central nervous system, specific populations of neurons are vulnerable in each disease, suggesting that selective neuronal vulnerability arises from intrinsic properties of the mutant proteins.
The central hypothesis of this proposal, based on preliminary data, is that neurotoxici…
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
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