CORDIS Project
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PoreMADNeSS focuses on designing synthetic membrane proteins, specifically transmembrane β-barrels, for use as nanopore sensors. The project aims to advance protein design methodologies to create sensors with novel properties for various applications.
Proteins embedded in membranes play key roles in maintaining cell integrity, homeostasis and communication.
Emerging technologies (nanopore sequencing, synthetic cells, …) imitate biological systems and repurpose membrane protein for the transport and sensing of new analytes through synthetic membranes.
These applications have fuelled the demand for (synthetic) membrane proteins with properties and functions not observed in nature.
Structure-based computational protein design is revolutionizing…
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