CORDIS Project
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The PORTAL project focuses on developing apolipoprotein nanoparticles to enhance the delivery of mRNA across the blood-brain barrier for treating neurological disorders. By screening various apolipoprotein formulations, the project aims to identify effective candidates for brain-targeted mRNA therapies.
Efficient therapeutic delivery across the blood-brain barrier (BBB) remains a significant challenge in treating neurological disorders.
The BBB, composed of tightly regulated endothelial cells, severely restricts drug access to the brain, reducing efficacy and increasing off-target effects.
While lipid nanoparticles (LNPs) have been essential for developing mRNA-based vaccines, their use in brain-targeted therapies is limited by poor BBB penetration and suboptimal mRNA translation.Apolipoprotein…
TECHNISCHE UNIVERSITEIT EINDHOVEN
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TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Israel, Haifa
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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