CORDIS Project
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The project focuses on developing an automated bioreactor platform to enhance the production of human induced pluripotent stem cells. It aims to improve efficiency and reproducibility in stem cell expansion and differentiation processes.
Human induced pluripotent stem cells (hiPSCs) have the potential to revolutionize biomedical sciences, however the standardised mass production, indispensable for their industrial and therapeutic use, is still a major challenge.
Impeller stirred-tank bioreactors, currently used for hiPSC bioprocessing, impose detrimental stresses on cultured hiPSCs, resulting in heterogeneity of cells and cell-aggregates, limited bioprocess reproducibility, and low hiPSC expansion efficiency at high costs.
The a…
MEDIZINISCHE HOCHSCHULE HANNOVER
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