CORDIS Project
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This project investigates how immune cells recognize pathogens over self-antigens to improve T cell activation. By studying the role of specific proteins in antigen presentation, the research aims to enhance vaccine development and therapies for infectious diseases.
ImImmune clearance of infectious diseases requires correct T cell activation by macrophages and dendritic cells (DCs) that present peptides derived from ingested pathogens on major histocompatibility complexes (MHC).
Yet, macrophages and DCs also ingest self-antigens present in healthy cells and their presentation might trigger autoimmune disease.
Presentation of the minority of ingested pathogens is promoted by so-called phagosome-autonomous trafficking.
Here, pathogen binding to Toll-like rece…
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