CORDIS Project
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This project investigates the regulatory networks of RNA that maintain adult germline stem cells in Drosophila melanogaster. By understanding how these networks control self-renewal and differentiation, the research aims to enhance knowledge applicable to regenerative medicine and age-related diseases.
Adult stem cells (SCs), also known as tissue SCs, support tissue homeostasis and repair throughout the entire life of the organism.
The remarkable longevity of tissue SCs relies on their unique ability to asymmetrically generate new SCs (self-renewal) as well as specialized cell types (differentiation).
Notably, many genes that signal to regulate the balance between renewal and differentiation encode proteins as well as small RNA molecules, predicted to regulate specific mRNAs.
This proposal is…
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