CORDIS Project
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This project investigates how a specific enzyme, NOX1, contributes to the hyperactivity of platelets in type 2 diabetes mellitus, leading to increased cardiovascular risks. By studying human blood samples and animal models, the research aims to clarify the molecular mechanisms involved and evaluate the potential of NOX…
Platelets are circulating blood cells that help to arrest of bleeding (i.e. haemostasis) and promote the repair of blood vessels following injury.
In type 2 diabetes mellitus (T2DM), platelets are hyperactive and their uncontrolled activation leads to the unwanted occlusion of blood vessels (i.e. thrombosis).
Thrombosis is the main cause of mortality for T2DM patients, who display significantly higher risk of cardiovascular disease than the rest of the population.
Currently, 70% of T2DM patients…
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
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