CORDIS Project
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This project investigates the role of RNA-protein interactions in the cellular response to DNA damage. By utilizing advanced biochemical and computational techniques, it aims to uncover how post-transcriptional regulation influences DNA repair and cell survival, potentially leading to new cancer treatment strategies.
The proposed project aims to identify the dynamics of RNA-protein interactions during DNA damage response (DDR) using high-throughput “omics” approaches.The mechanistic basis of DDR has been classically thought to consist of an ""early"" post-translational response, which results in activation of several signalling pathways and transciption factors.
These activate the ""late"" transcriptional reprogramming influencing DNA repair, cell cycle regulation and apoptosis.
However, for an immediate and…
MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)
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