CORDIS Project
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This project aims to develop less invasive treatments for inherited metabolic liver diseases by combining gene therapy with stem cell technology. It focuses on reprogramming patient-specific liver cells to create a viable alternative to liver transplantation.
Currently, the only cure for many inherited metabolic liver diseases with severe extra-hepatic manifestations, such as Crigler-Najjar disease (CNI), is liver transplantation (LT). LT goes together with heavy surgery, life-long immunosuppression and important public health costs.
Development of less invasive treatments will permit important benefits for the patients and economic savings.
Combination of gene therapy and hepatocyte (HEP) transplantation is a promising alternative to LT, correcting…
UNIVERSITE DE GENEVE
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