CORDIS Project
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This project examines the role of the SMYD3 protein in muscle development by regulating gene expression during myogenesis. Using muscle cell models, it investigates how SMYD3 influences muscle-specific genes and cellular fusion processes.
SMYD3 is a histone methylase that di- and tri-methylates histone H3 at lysine 4.
In normal conditions SMYD3 is highly expressed only in skeletal muscle and testis.
We hypothesize that SMYD3 plays an important role in transcriptional regulation throughout myogenesis.
We will use C2C12 myoblast and primary satellite cells as model systems to assess the contribution of SMYD3 to the transcriptional regulation of muscle specific genes.
We will over-express and knock down SMYD3 to determine the impact…
UNIVERSITA DEGLI STUDI DI MILANO
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