CORDIS Project
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This project investigates the role of Peroxisome Proliferator-Activated Receptor gamma (PPARγ) in regulating immune responses and its connection to metabolic processes. Using mouse models, it aims to clarify how PPARγ influences inflammation and immune cell differentiation through microRNA signaling.
Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear receptor superfamily whose ligands are liophilic compounds.
Early studies on PPARs action revealed their role in diverse aspects in development and homeostasis.
Despite the substantial research effort targeting PPARs role in metabolism including lipid metabolism, glucose homeostasis and adipogenesis the exact mechanisms by which PPARs regulate metabolic processes are poorly understood.
Yet another facet of PPARs action is…
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