CORDIS Project
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This project explores the role of protein prenylation in cell function and disease, particularly in cancer and vision. It aims to understand the transport and regulation of specific proteins in the model organism C. elegans.
Protein prenylation is essential for the viability of all eukaryotic cells.
Prenylated proteins regulate fundamental processes such as cell growth, differentiation and movement.
Therefore, it is not surprising that prenylated proteins play a critical role in the pathophysiology of human diseases such as cancer and atherosclerosis.
Indeed, mutations in the farnesylated oncogene Ras are found in 10-15% of all human tumors.
Recent studies demonstrated that PDE6D acts as a soluble chaperon of Ras,…
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