CORDIS Project
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This project aims to explore protein-RNA interactions that regulate mRNA processes, particularly in the context of Amyotrophic Lateral Sclerosis (ALS). By studying various cellular models, it seeks to uncover the mechanisms that control mRNA localization and translation in motor neurons.
Interactions between proteins and RNAs regulate processing, localization, decay and translational regulation of mRNAs.
Recently, it was revealed that the number of putative RBPs in mammalian cells is about three times larger than appreciated.
However, the exposed interaction network was inspected only in a single given state; furthermore the functional gene expression mechanism is yet unknown.
In my proposed project, we aim to inspect the differences in global protein-occupancy on mRNAs and iden…
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