CORDIS Project
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This project investigates a newly discovered cofactor involved in bacterial ubiquinone biosynthesis and the biodegradation of aromatic compounds. It focuses on understanding the structure and function of the UbiD enzyme family to develop green methods for producing commodity chemicals.
Our group has recently discovered a new type of cofactor: a prenylated-flavin that has azomethine ylide properties.
This cofactor is an integral part of the widespread ubiD/ubiX system.
The latter is implicated in the non-oxidative reversible decarboxylation of aromatic substrates, and plays a pivotal role in bacterial ubiquinone biosynthesis or microbial biodegradation of aromatic compounds.
We established UbiX acts as a novel flavin prenyltransferase, linking a dimethylallyl moiety to the fla…
THE UNIVERSITY OF MANCHESTER
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