CORDIS Project
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This project focuses on understanding the molecular mechanisms that ensure accurate chromosome segregation during cell division. By studying the interactions between spindle microtubules and kinetochores, it aims to uncover the causes of chromosomal errors linked to cancer.
At any given moment, 250 million cells are dividing in the human body through an essential process known as mitosis.
Inaccuracy of mitosis leads directly to aneuploidy (gain or loss of chromosomes), a hallmark of several cancers and birth defects.
Mitotic fidelity is controlled by the spindle assembly checkpoint (SAC), a signaling pathway that delays the progression of mitosis to ensure that all chromosomes are attached to mitotic spindle microtubules (MTs).
Central to this activity, the kinetoc…
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