CORDIS Project
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This research develops a strategy called 'Precision Lethality' to enhance drug treatment for neuroblastoma by using cell barcoding techniques. It aims to identify and target specific subclonal populations within tumors, thereby improving the effectiveness of drug combinations and addressing clonal heterogeneity.
Tumors are heterogeneous in nature due to genetic instabilitTumors are heterogeneous in nature due to genetic instability, ongoing selection, and variable microenvironments with local adaptation.
Many tumors thus necessitate combinatorial drug treatments to reach all cells.
This is true also for neuroblastoma, the most common extracranial solid pediatric tumor.
Despite the well-known importance of clonal heterogeneity, most in vitro drug combination strategies, including commonly used synergisti…
KAROLINSKA INSTITUTET
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