CORDIS Project
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This project investigates the protective effects of slow-release hydrogen sulfide compounds against complications from diabetes. By targeting oxidative stress and inflammation in blood vessels, the research aims to develop treatments that could mitigate long-term diabetic complications.
Diabetic complications are the leading cause of morbidity and mortality in diabetic patients.
Oxidative stress and inflammation contributes to the loss of endothelial function and dysfunction of the vascular endothelium plays a major role in diabetic macrovascular and microvascular complications.
We found that hydrogen sulfide can reduce the hyperglycemia-induced mitochondrial reactive oxygen species (ROS) production in endothelial cells and can prevent diabetic vascular dysfunction in aortic ri…
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