CORDIS Project
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PrediKSion is a computational pipeline designed to uncover the hidden chemical functionalities of uncharacterized trans-acyltransferase polyketide synthase modules. By analyzing the evolutionary relationships of these enzymes, it aims to facilitate the discovery of new biosynthetic features and metabolites with potenti…
Many of the most valuable, yet complex chemicals in society are obtained from bacteria, who use giant, multimodular acyltransferase polyketide synthase (AT PKS) enzyme complexes to make these products.
The modular nature of these enzymes holds the promise to engineer biosynthetic assembly lines to produce new, societally relevant products in a benign and sustainable manner.
However, the chemical functionalities installed by the textbook cis-AT PKSs is mostly limited to several basic moieties.In…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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