CORDIS Project
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This project investigates how experiences reshape synaptic connections in the medial prefrontal cortex, a brain region crucial for decision-making. By employing advanced techniques like optogenetics and calcium imaging, it aims to map the connectivity of neurons and understand how learning alters these connections.
How does experience alter the functional architecture of synaptic connections in neural circuits?
This question is particularly pertinent for the complex circuits of the medial prefrontal cortex (mPFC), a high-order associative neocortical area that plays a crucial role in flexible, goal-directed behavior.
The mPFC is densely interconnected with cortical and subcortical circuits, and its neurons were shown to undergo substantial experience-dependent structural remodeling that is thought to suppo…
WEIZMANN INSTITUTE OF SCIENCE
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