CORDIS Project
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The project investigates Clonal Hematopoiesis, a condition linked to blood cancers, by examining the effects of aging and genetic mutations on hematopoietic stem cells. It aims to understand the microenvironmental factors that contribute to the survival and proliferation of mutated cell clones.
Clonal Hematopoiesis (CH) is an age related state in which a single and genetically defined Hematopoietic Stem Cell (HSC) contributes more than expected to the hematopoietic pool, due to the selective advantage conferred by genetic variants termed preleukemic mutations (pLMs). CH is a significant risk factor for hematological malignancies such as Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS).
Today, the mechanisms by which pLMs provide selective advantage and why in some cases…
WEIZMANN INSTITUTE OF SCIENCE
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