CORDIS Project
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This project addresses Long QT Syndrome by developing in vitro models using human stem cell-derived heart cells. It aims to understand the variability in disease severity and improve drug testing for arrhythmias, promoting personalized medicine.
Long QT Syndrome (LQTS) is a severe arrhythmogenic condition characterised by the prolongation of the QT interval on the electrocardiogram.
It is caused by genetic factors (congenital) or drugs (acquired) and sudden cardiac death can be the first manifestations of the disease.
Advancements in genetic screenings have revealed profound links between genotype and phenotype for LQTS, improving diagnosis, risk stratification and therapy;
However, it is still poorly understood why patients with identi…
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