CORDIS Project
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The PREMNEC project investigates necrotising enterocolitis in preterm infants using a novel human intestinal model. It aims to explore the gut microbiome and host interactions to better understand disease mechanisms and identify protective bacterial species.
Necrotising enterocolitis (NEC) is an inflammatory mediated bowel disease that causes more deaths after the first week of life in extremely preterm infants than any other single pathology, with prematurity and abnormal bacterial colonisation regarded as the most significant risk factors.
However, 40 years of research have yielded few advances in treatment and the mechanisms of disease remain poorly understood. A major reason for this lack of progress relates to challenges in translating findings…
UNIVERSITY OF NEWCASTLE UPON TYNE
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