CORDIS Project
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This project explores the genetic adaptation of humans to malaria, particularly focusing on the sickle cell trait among African populations. It aims to determine if this trait was selected before the advent of agriculture, reshaping our understanding of human evolution in relation to malaria.
Tertian malignant malaria (or malaria for short) currently kills more than 400k people per year in sub-Saharan Africa.
Malaria probably became endemic in that region during the Neolithic transition, due to the spread of agriculture, thus imposing a strong selective pressure on the human genome.
As a consequence, sickle cell anemia, a genetic disease that protects against malaria, is thought to have been selected and maintained at high frequencies among sub-Saharan farmers (Bantus) by balancing s…
THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS
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