CORDIS Project
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This project explores the mechanisms behind insulin resistance and type 2 diabetes, particularly the role of glucocorticoids in muscle metabolism. It aims to identify therapeutic targets to improve insulin sensitivity and understand lipid metabolism in muscle tissue.
Currently, there is an urgent need to understand the pathogenesis underpinning insulin resistance (IR) and type 2 diabetes (T2DM), due to their dramatically increasing prevalence.
Glucocorticoids (GCs) are potent modulators of skeletal (Sk) muscle insulin sensitivity, as exemplified in patients with GC excess, Cushing’s syndrome, who develop IR and T2DM.
Importantly, increased GC generation locally in muscle may contribute to the phenotype in T2DM patients.
Although the precise molecular mechani…
THE UNIVERSITY OF BIRMINGHAM
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Canada, Toronto
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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