CORDIS Project
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This research investigates the impact of retrotransposons on human neuronal gene expression using cortical organoids. It aims to understand how these elements influence gene regulation and their potential link to neurological diseases.
Throughout evolution, the human genome has been attacked by retrotransposons, parasitic DNA elements that spread through our genome by a copy-paste activity. I previously showed that SVA elements, the youngest class of retrotransposons in our genome, harbour a strong gene-regulatory potential which is normally repressed by KRAB zinc finger protein ZNF91 (Jacobs et al., 2014, Nature).
However, for reasons unknown, repression of retrotransposons is much less efficient in the human brain, resultin…
UNIVERSITEIT VAN AMSTERDAM
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