CORDIS Project
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This project investigates the mechanisms behind L-dopa-induced dyskinesia in Parkinson's disease. It aims to understand how brain responses to dopamine change over time and develop new treatment approaches to improve patient outcomes.
L-dopa-induced dyskinesia (LID) severely limits the usability of L-dopa in Parkinson’s disease (PD) patients and a treatment is needed to improve their quality of life.
The project aims at elucidating the “priming” phenomenon in PD, i.e. the unchangeable modification of brain response to dopamine (DA), that leads to the development of LID.
We will investigate the role of neurotransmitter receptor homologous desensitization and its consequences upon main intracellular signalling cascades, i.e. th…
UNIVERSITE VICTOR SEGALEN BORDEAUX II
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