CORDIS Project
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This project examines the role of a protein called PrPC in neurodegenerative disorders, particularly focusing on its interactions and functions in maintaining nerve health. By studying the mechanisms of protein aggregation, it aims to uncover insights applicable to various protein misfolding diseases.
Oligomers are toxic in an array of protein misfolding and aggregation (PMA) disorders.
However, the chain of events from protein aggregation to dysfunction is poorly understood.
Prion diseases are marked by accumulation of PrPSc, a misfolded variant of wild-type PrPC.
PrPC mediates PrPSc neurotoxicity and counteracts toxic PrPC mutants, indicating that a subversion of normal PrPC function may underlie neurodegeneration, and this may not be limited to prion disease.
Here, we propose to explore th…
University of Zurich
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