CORDIS Project
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This project explores the degradation of proteins modified by non-enzymatic processes, which can compromise cellular function. By identifying the mechanisms that lead to the clearance of these damaged proteins, the research aims to enhance understanding of protein quality control in health and disease.
Cellular homeostasis and survival critically depend on the ability to remove misfolded and damaged proteins.
In cells, proteins are continuously exposed to reactive metabolites which introduce modifications such as oxidation, carbonylation, glycation or carbamylation.
Such non-enzymatic post-translational modifications (nePTM) can irreversibly block critical interaction surfaces or reactive sites and thus pose a constant threat to proteome integrity.
In line with this view, levels of nePTM are i…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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