CORDIS Project
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This project investigates a new form of cellular senescence triggered by the inactivation of the Pten gene, which may prevent early cancer progression. It explores the mechanisms behind this process and its potential therapeutic applications, particularly in treating pediatric brain tumors using p53 stabilizing drugs a…
The irreversible cell growth arrest, termed cellular senescence, is emerging as an intrinsic tumour suppressive mechanism, which restricts progression of early cancerous lesions in humans.
We have recently reported, a new type of cellular senescence, which occurs after the acute inactivation of the tumour suppressor Pten and significantly opposes tumorigenesis in vivo.
Pten induced cellular senescence (PICS) occurs at early time points after Pten inactivation even in absence of cellular prolifer…
Ente Ospedaliero Cantonale
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Italy, ROMA
Type: Public body
Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
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