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The ProAct project aims to enhance interferometric scattering microscopy to study protein conformational changes by measuring dielectrophoretic forces. This innovative approach allows for label-free observation of protein dynamics, providing insights into protein behavior and interactions in biological systems.
Proteins carry out all functions in living cells, from division, metabolism and transport to programmed cell death.
Understanding how protein structure and movements relate to their function is key to advancing biology and medicine. A recent breakthrough, interferometric scattering (iSCAT) microscopy, allows us to observe single protein molecules without using fluorescent labels or chemical tethers.
This innovation enables label-free protein studies but currently cannot detect changes in protein…
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