CORDIS Project
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This project focuses on developing a method for the total chemical synthesis of conditional Major Histocompatibility Complex platforms, enabling high-throughput generation of various MHC alleles. By utilizing solid phase peptide synthesis, it aims to enhance T cell visualization and improve T cell therapies for biomedi…
Technologies for T cell visualisation and T cell depletion/enrichment are steadily making their way into the clinic and developments seem dictated by availability and reliability of the peptide-Major Histocompatibility Complex (pMHC) reagents used. A bottleneck has always been the laborious process of expression, refolding and purification of individual pMHCs.
Recently, conditional MHC technology, pioneered in the host laboratory, solved this problem in part by enabling high-throughput loading o…
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
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