CORDIS Project
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This project explores the role of GPR37, a receptor linked to Parkinson's disease, in neuroprotection and disease progression. It aims to understand the receptor's interactions and develop potential diagnostic and therapeutic applications based on its mechanisms.
The next breakthrough in the treatment of synucleinopathies, incl Parkinson´s disease (PD), will be aimed at interference of disease progression based on insights into the underlying pathogenic process.
The pathological hallmark of PD are Lewy bodies (LBs), in which α-synuclein is the major constituent together with other PD-linked gene products (DJ-1, LRRK2, parkin, and GBA) and aggregated GPR37. GPR37 is exceptional among GPCRs having a high propensity for intracellular receptor accumulation a…
KAROLINSKA INSTITUTET
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